Foye's Principles of Medicinal Chemistry

Foye's
Principles of Medicinal Chemistry
Sixth Edition
edited by Thomas L. Lemke

Foye's Principles of Medicinal Chemistry, 6th edition has been fully revised and updated. Emphasis is on patient-focused pharmaceutical care and on the pharmacist as a therapeutic consultant, rather than a chemist.

A new disease state management section explains appropriate therapeutic options for asthma, chronic obstructive pulmonary disease, and men's and women's health problems.

Also new to this edition:

• Clinical Significance boxes
• Drug Lists at the beginning of appropriate chapters
• an eight-page color insert with detailed illustrations of drug structures

Contents

Part I: Principles of Drug Discovery

1. Drug Discovery from Natural Products
2. Drug Design and Relationship of Functional Groups to Pharmacologic Activity
3. Molecular Modeling and in Silico
4. Receptors and Drug Action
5. Drug Discovery Through Enzyme Inhibition
6. Pharmaceutical Biotechnology-From Nucleic Acids to Personalized Medicine
7. Peptide and Protein Drugs
8. Antisense Therapeutic Agents
9. Physicochemical and Biopharmaceutical Properties of Drug Substances and Pharmacokinetics
10. Drug Metabolism
11. Drug Regulation: An Overview

Part II: Drug Receptors Affecting Neurotransmission and Enzymes as Catalytic Receptors

12. Drugs Affecting Cholinergic Neurotransmission
13. Adrenergic Receptors and Drugs Affecting Adrenergic Neurotransmission
14. Serotonin Receptors and Drugs Affecting Serotonergic Neurotransmission
15. Amino Acid Neurotransmitters in the Central Nervous System
16. Inhibitors of Nerve Conduction: Local Anesthetics
17. Phosphodiesterase Inhibitors

Part III: Pharmacodynamic Agents

Section 1: Drugs Affecting Central Nervous System

18. General Anesthetics
19. Sedative-Hypnotics
20. Antiseizure Agents
21. Antidepressants
22. Psychotherapeutic Drugs: Antipsychotic and Anxiolytic Agents
23. Hallucinogens, Stimulants and Related Drugs of Abuse
24. Opioid Analgesics
25. Drugs Used to Treat Neuromuscular Disorders: Antiparkinsonian and Spasmolytic Agents

Section 2: Drugs Affecting the Cardiovascular System

26. Cardiac Agents: Cardiac Glycosides, Antianginal, and Antiarrhythmic Drugs
27. Diuretics
28. Angiotensin Converting Enzyme Inhibitors, Antagonists and Calcium Blockers
29. Central and Peripheral Sympatholytics and Vasodilators
30. Antihyperlipoproteinemics and Inhibitors of Cholesterol Biosynthesis
31. Antithrombotics, Thrombolytics, Coagulants, and Plasma Extenders

Section 3: Drugs Affecting the Hormonal Systems

32. Insulin and Drugs Used for the Treatment of Diabetes
33. Adrenocorticoids
34. Thyroid Function and Thyroid Drugs
35. Calcium Homeostasis Section 4: Drugs Affecting the Immune Systems

Section 4: Drugs Affecting the Immune System

36. Nonsteroidal Anti-Inflammatory Drugs
37. Antihistamines and Related Antiallergic and Antiulcer Agents

Section 5: Chemotherapeutic Agents

38. Antibiotics and Antimicrobial Agents
39. Antiparasitic Agents
40. Antifungal Agents
41. Antimycobacterial Agents
42. Cancer and Chemotherapy
43. Antiviral Agents and Protease Inhibitors

Part IV: Disease State Management

44. Asthma and Chronic Obstructive Pulmonary Disease
45. Men' Health
46. Women's Health

Appendices

• pKa Values for Some Drugs and Miscellaneous Organic Acids and Bases
• pH Values for Tissue Fluids

Index

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