Biopharmaceuticals : Biochemistry and Biotechnology

Book Description

The latest edition of this highly acclaimed textbook, provides a comprehensive and up-to-date overview of the science and medical applications of biopharmaceutical products. Biopharmaceuticals refers to pharmaceutical substances derived from biological sources, and increasingly, it is synonymous with ‘newer’ pharmaceutical substances derived from genetic engineering or hybridoma technology.

This superbly written review of the important areas of investigation in the field, covers drug production, plus the biochemical and molecular mechanisms of action together with the biotechnology of major biopharmaceutical types on the market or currently under development. There is also additional material reflecting both the technical advances in the area and detailed information on key topics such as the influence of genomics on drug discovery.

Table of Contents

Preface
Ch. 1 Pharmaceuticals, biologics and biopharmaceuticals 1
Ch. 2 The drug development process 43
Ch. 3 The drug manufacturing process 93
Ch. 4 The cyotkines – the interferon family 189
Ch. 5 Cytokines: interleukins and tumour necrosis factor 223
Ch. 6 Haemopoietic growth factors 255
Ch. 7 Growth factors 277
Ch. 8 Hormones of therapeutic interest 303
Ch. 9 Blood products and therapeutic enzymes 351
Ch. 10 Antibodies, vaccines and adjuvants 403
Ch. 11 Nucleic acid therapeutics 463
App. 1 Biopharmaceuticals thus far approved in the USA or European Union 499
App. 2 Some Internet addresses relevant to the biopharmaceutical sector 509
App. 3 Two selected monographs reproduced from the European Pharmacopoeia (Products of recombinant DNA technology; Interferon a-2 concentrated solution) 515
App. 4 Manufacture of biological medicinal products for human use 527
Index 533

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Applied Biopharmaceutics Pharmacokinetics by Leon Shargel

By Leon Shargel, Susanna Wu-Pong, Andrew B.C. Yu,

Publisher: McGraw-Hill Medical
Number Of Pages: 892
Publication Date: 2004-08-19
Sales Rank: 97141
ISBN / ASIN: 0071375503
EAN: 9780071375504
Binding: Hardcover
Manufacturer: McGraw-Hill Medical
Studio: McGraw-Hill Medical
Average Rating: 4

The primary emphasis of this book is on the application and understanding of concepts. Basic theoretical discussions of the principles ofbiopharmaceutics and pharmacokinetics are provided, along with illustrative examples and practiceproblem and solution to help the student gain skill in practical problem solving.

Review:

Great Condition and Timely Delivery

The book was sent in excellent condition and it was received quickly. It has no highlights or ripped pages. The seller was honest about the quality of the book and easy to communicate with.

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Preclinical Development Handbook: ADME and Biopharmaceutical Properties

Preclinical Development Handbook: ADME and Biopharmaceutical Properties (Pharmaceutical Development Series)
By Shayne Cox Gad

Publisher: Wiley-Interscience
Number Of Pages: 1329
Publication Date: 2008-03-14
ISBN-10 / ASIN: 0470248475
ISBN-13 / EAN: 9780470248478
Binding: Hardcover

A clear, straightforward resource to guide you through preclinical drug development

Following this book’s step-by-step guidance, you can successfully initiate and complete critical phases of preclinical drug development. The book serves as a basic, comprehensive reference to prioritizing and optimizing leads, dose formulation, ADME, pharmacokinetics, modeling, and regulations. This authoritative, easy-to-use resource covers all the issues that need to be considered and provides detailed instructions for current methods and techniques.

Each chapter is written by one or more leading experts in the field. These authors, representing the many disciplines involved in preclinical toxicology screening and testing, give you the tools needed to apply an effective multidisciplinary approach. The editor has carefully reviewed all the chapters to ensure that each one is thorough, accurate, and clear.

Among the key topics covered are:
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Modeling and informatics in drug design
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Bioanalytical chemistry
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Absorption of drugs after oral administration
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Transporter interactions in the ADME pathway of drugs
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Metabolism kinetics
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Mechanisms and consequences of drug-drug interactions

Each chapter offers a full exploration of problems that may be encountered and their solutions. The authors also set forth the limitations of various methods and techniques used in determining the safety and efficacy of a drug during the preclinical stage.

This publication should be readily accessible to all pharmaceutical scientists involved in preclinical testing, enabling them to perform and document preclinical safety tests to meet all FDA requirements before clinical trials may begin.

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Pharmacokinetics in Drug Discovery and Development

Pharmacokinetics in Drug Discovery and Development
By Ronald D. Schoenwald

Publisher: CRC
Number Of Pages: 440
Publication Date: 2002-03-06
ISBN-10 / ASIN: 1566769736
ISBN-13 / EAN: 9781566769730
Binding: Hardcover

Pharmacokinetics has evolved from its origin into a complex discipline with numerous subspecialties and applications in patient management, drug development, and regulatory issues. This expansion has made it difficult for any one individual to become a full-fledged expert in all areas. Fulfilling the need for a wide-ranging guide to the many existing subspecialties in this field, Pharmacokinetics in Drug Discovery and Development details the different areas in the field providing the ideal comprehensive, quick access text and reference. After an introduction of basic principles, the book is divided into sections that cover industrial and regulatory applications, clinical applications, and research applications. The following sections cover such topics as PK/PD approaches, clinical pharmacokinetic monitoring, population pharmacokinetics, linear systems approaches, and more. Fourteen authors, each an expert in his/her area of expertise, provide an extensive background into the subspeciality with emphasis on the section’s theme. Covering the many sub-disciplines and providing pharmacokinetic concepts, terminology, and approaches, Pharmacokinetics in Drug Discovery and Development serves as a resource for professionals throughout this field.

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Applied Clinical Pharmacokinetics, 2nd edition

Applied Clinical Pharmacokinetics
By Larry A. Bauer

Publisher: McGraw-Hill Medical
Number Of Pages: 800
Publication Date: 2008-06-24
ISBN-10 / ASIN: 0071476288
ISBN-13 / EAN: 9780071476287
Binding: Hardcover

>The easiest and most trusted way to learn the clinical application of pharmacokinetics

The most current, hands-on book in the field, Applied Clinical Pharmacokinetics gives you clear and useful coverage of drug dosing and drug monitoring that no other text can match. It offers the latest standardized techniques and approaches to patient-specific dosing plus new information on more recently monitored drugs.

Written by a nationally recognized authority in pharmacokinetics, Applied Clinical Pharmacokinetics is full of essential topics for pharmaceutics, pharmacokinetics, therapeutics, and clinical pharmacy courses. Alternatively, it can be used as a clinical refresher to brush up on key concepts and procedures.

FEATURES

NEW! High-yield sections on dosing strategies in all chapters
NEW! Up-to-date, ready-to-use information on monitored drugs
Valuable coverage of drug dosing in special populations, including patients with renal and hepatic disease, obesity, and congestive heart failure and patients on dialysis
All the information that practitioners need regarding drug categories such as antibiotics, cardiovascular agents, anticonvulsants, and immunosuppressants
Tools to simplify learning throughout, such as an introductory chapter on clinical pharmacokinetic and pharmacodynamic concepts, examples of calculations, and problems with answers and explanations at the end of each chapter

Summary: The best current kinetics book.
Rating: 5

Bauer does an excellent job of explaining the basics and details of pharmacokinetics; this book is great guide for both students and practicing clinicians. Many pharmacokinetic residents and fellows live by this book and it came highly reccommended to me by experienced clinicians.

Summary: Nuts and bolts kinetics
Rating: 5

As you read this text it becomes apparent that it was written by an in-the-trenches clinical pharmacist. It focuses on the practical application of pharmacokinetics in patient care. The text is very readable, written in an easy to follow style. The tables and illustrations are well presented, providing insight to the topic. There are chapters on aminoglycosides, vancomycin, digoxin, antiarrhythmics, anticonvulsants, cylcosporine, lithium, and theophylline. Each chapter contains practical step-by-step examples for both initial dosage determinations and serum level analysis. But you’ll need to look elsewhere for pediatric pk information, application to peds is limited.

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