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Posted by Piscean on Thursday, November 26, 2009
Drug-Drug Interaction Primer: A Compendium of Case Vignettes for the Practicing Clinician
By Neil B., M.d. Sandson
Publisher: American Psychiatric Publishing
Number Of Pages: 408
Publication Date: 2007-06-05
ISBN-10 / ASIN: 1585623059
ISBN-13 / EAN: 9781585623051
Binding: Paperback
This user-friendly resource offers complete and comprehensive coverage of the difficult challenges posed by drug-drug interactions. Over 170 case vignettes illustrate a variety of interactions (DDIs) to provide an unintimidating even entertaining approach to understanding these issues. Drug-Drug Interaction Primer builds on the author’s earlier work, Drug Interactions Casebook: The Cytochrome P450 System and Beyond, and features updated references throughout and 29 new cases that provide such clinical examples as: a patient diagnosed with schizoaffective disorder transitions from haloperidol to aripiprazole with disastrous results; an AIDS patient’s trimethoprim-sulfamethoxazole is replaced with warfarin following atrial fibrillation, resulting in ischemic stroke; and a delusional patient on risperidone is placed on phenytoin following seizures, and delusions return. Previous cases have been revised to enhance clarity.
An introduction to core concepts, which includes brief reviews of each enzyme system, brings the reader up to speed on how to think about DDIs and begin to grapple with what might seem like an imposing subject. The vignettes that follow each include a case presentation and an explanation of the mechanism by which the interaction(s) occurred, and each derives from sound clinical evidence not merely extrapolations from drug characteristics to offer a more realistic understanding of DDIs. Most of the interactions described involve the cytochrome P450 enzyme system; others involve alterations in phase II metabolism and P-glycoprotein functioning, as well as plasma protein displacement effects. The appendices detail most drug-drug interactions between psychotropic agents and contain metabolic pathways and inhibitory and inductive profiles for antidepressants, antipsychotics, and mood stabilizing agents as well as tables that detail all known and clinically significant DDIs between pairings of any two agents from these drug classes. An extensive index allows quick reference. Among the book’s other features:
Reorganization by medical subspecialty psychiatry, internal medicine, neurology, surgery/anesthesia, and gynecology, oncology, and dermatology better facilitates clinical application.
Comprehensive tables detail substrates, inhibitors, and inducers for P450, phase II, and P-glycoprotein.
DDIs involving select nonpsychotropic agents such as tobacco, ethinylestradiol, and statins.
Exploration of the paradigm of plasma protein binding mediated DDIs in detail, with cases conveniently indexed.
These cases bring DDIs alive in a way that drier descriptions cannot, and this volume introduces more original material than will be found in other sources. Drug-Drug Interaction Primer is brimming with material that can be put to immediate use, offering insights that will improve any practitioner’s skills.
Posted by Piscean on Thursday, November 12, 2009
Handbook of Drug Interactions: A Clinical and Forensic Guide (Forensic Science and Medicine) (Forensic Science and Medicine)
By Ashraf Mozayani, Lionel P. Raymon
Publisher: Humana Press
Number Of Pages: 680
Publication Date: 2003-10-15
ISBN-10 / ASIN: 1588292118
ISBN-13 / EAN: 9781588292117
Binding: Hardcover
A concise compilation of the known interactions of the most commonly prescribed drugs, as well as their interaction with nonprescription compounds. The agents covered include CNS drugs, cardiovascular drugs, antibiotics, and NSAIDs. For each class of drugs the authors review the pharmacology, pharmacodynamics, pharmacokinetics, chemistry, metabolism, epidemiological occurrences, adverse reactions, and significant interactions. Environmental and social pharmacological issues are also addressed in chapters on food and alcoholdrug interactions, nicotine and tobacco, and anabolic doping agents.
Comprehensive and easy-to-use, Handbook of Drug Interactions: A Clinical and Forensic Guide provides physicians with all the information needed to avoid prescribing drugs with undesirable interactions, and toxicologists with all the data necessary to interpret possible interactions between drugs found simultaneously in patient samples.
Summary: An Excellent Book…Long Due for Publication
Rating: 5
Posted by Piscean on Wednesday, October 21, 2009
Manual of Drug Interaction Principles for Medical Practice: The P450 System (Concise Guides)
By Gary H. Wynn
Publisher: American Psychiatric Publishing, Inc.
Number Of Pages: 618
Publication Date: 2008-10-30
ISBN-10 / ASIN: 1585622966
ISBN-13 / EAN: 9781585622962
Product Description:
As every healthcare provider knows, drug-drug interactions are as prevalent as they are preventable. The Clinical Manual of Drug Interaction Principles for Medical Practice is an exceptionally practical, thoroughly up-to-date resource to help psychiatric clinicians (including residents and nurses) understand and avoid potentially dangerous interactions and provide the highest standard of patient care. Many new medications have entered the market in recent years and knowledge of pharmacokinetics and pharmacogenetics has grown significantly. From earlier versions in concise guide format, the authors have evolved this new and enlarged Manual offering the expanded coverage and features that clinicians need to keep up with this critical field. Major sections cover metabolism (with new, expanded coverage of transporters); cytochrome P450 enzymes; up-to-date coverage of drug interactions by medical specialty; and practical matters, such as the medicolegal implications of drug-drug interactions and how to retrieve and review the literature. Each chapter includes extensive references and study cases to help the reader understand and contextualize the information. A summary table of drugs by specialty and their metabolic sites provides ready reference. The book s comprehensive coverage reflects the very latest research, and its user-friendly format will make it indispensable to anyone engaged in direct patient care.
Summary: Filled with complete and comprehensive and up to date research on drug interaction
Rating: 5
The wrong mixture of over the counter drugs can be fatal, and doctors and pharmacists must be aware of these lethal combos. "Clinical Manual of Drug Interaction Principles for Medical Practice" is a scholarly work discussing this very real possibility that can be prevented with the right research and foresight. With the hundreds upon hundreds of new drugs entering the market every year, the research into this subject is now invaluable, as it could save thousands of lives. Filled with complete and comprehensive and up to date research on drug interaction, "Clinical Manual of Drug Interaction Principles" is strongly recommended for community and college library medicine collections.
Summary: Outstanding Reference
Rating: 5
This is the gold standard for drug interactions and should be part of any prescriber’s reference set. Meticulously researched, it is the most up to date synopsis of the expanding field of drug metabolism and interactions. The material can be a bit dense at times, but this is also the nature of the topic.
Posted by Piscean on Saturday, October 10, 2009
