Vogel Text book of Macro and semimicro qualitative inorganic analysis

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Structure Elucidation by NMR in Organic Chemistry

Structure Elucidation by NMR in Organic Chemistry
Publisher: Wiley | 3 edition (December 3, 2002) | ISBN: 0470850078 | Pages: 270 | PDF | 8.7 MB

This text provides the graduate student with a systematic guide to unravelling structural information from the NMR spectra of unknown synthetic and natural compounds. A brief introduction gives an overview of the basic principles and elementary instrumental methods of NMR. This is followed by instructional strategy and tactical advice on how to translate spectra into meaningful structural information. The book provides the student with 55 sets of spectra of graduated complexity. These are designed to challenge the student's problem-solving abilities by the introduction of new concepts with each group of problems, followed by possible solutions and full explanations. A formula index of solutions is provided at the end of the text. This third edition, following on from the second (a reprint of the first edition with corrections), presents significant new material. Thus, actual methods of two-dimensional NMR such as some inverse techniques of heteronuclear shift correlation, as well as the detection of proton-proton connectivities and nuclear Overhauser effects are included. To demonstrate the applications of these methods, new problems have replaced those of previous editions.

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Advances in Chromatography

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Rapid Microbiological Methods in the Pharmaceutical Industry

Rapid Microbiological Methods in the Pharmaceutical Industry
By Martin C. Easter

Publisher: CRC
Number Of Pages: 288
Publication Date: 2003-03-19
ISBN-10 / ASIN: 1574911414
ISBN-13 / EAN: 9781574911411
Binding: Hardcover

In recent years there has been increased interest in the possibility of rapid microbiological methods offering enhanced potential error detection capabilities. However, these methods raise a number of questions, such as how to validate new methods, will they be accepted by the pharmacopoeias, and, most importantly, how will the regulators respond? Rapid Microbiological Methods in the Pharmaceutical Industry answers these questions and more. Martin Easter and his panel of experts: § Describe the range of rapid microbiological methods and their applications, including practical tips, and their status regarding validation, established use, and regulatory acceptance § Explore the origins of current methods and the current issues facing the requirements of microbiology and its associated test methods § Delineate the challenges involved in seeking better and more pragmatic methods for the assessment of microbial hazards and risks to ensure product and consumer safety The book assists you in applying an effective system to assess the real microbiological hazards and, hence, quantify realistic risks. Additionally, it provides monitoring methods that will deliver meaningful, useful data for effective decision making in manufacturing, quality assurance, and product safety. The expert and authoritative information in Rapid Microbiological Methods in the Pharmaceutical Industry will help you find better solutions to ensuring the microbiological safety of pharmaceutical products. Features

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Pharmaceutical Dissolution Testing

Book Description

An expertly written source on the devices, systems, and technologies used in the dissolution testing of oral pharmaceutical dosage forms, this reference provides reader-friendly chapters on currently utilized equipment, equipment qualification, consideration of the gastrointestinal physiology in test design, the analysis and interpretation of data and procedure automation -laying the foundation for the creation of appropriate and useful dissolution tests according to the anticipated location and duration of drug release from the dosage form within the gastrointestinal tract.

Table of Contents

1 Historical development of dissolution testing 1
2 Compendial testing equipment : calibration, qualification, and sources of error 39
3 Compendial requirements of dissolution testing – European pharmacopoeia, Japanese pharmacopeia, United States pharmacopoeia 69
4 The role of dissolution testing in the regulation of pharmaceuticals : the FDA perspective 81
5 Gastrointestinal transit and drug absorption 97
6 Physiological parameters relevant to dissolution testing : hydrodynamic considerations 127
7 Development of dissolution tests on the basis of gastrointestinal physiology 193
8 Orally administered drug products : dissolution data analysis with a view to in vitro-in vivo correlation 229
9 Interpretation of in vitro-in vivo time profiles in terms of extent, rate, and shape 251
10 Study design considerations for IVIVC studies 281
11 Dissolution method development with a view to quality control 315
12 Dissolution method development : an industry perspective 351
13 Design and qualification of automated dissolution systems 373
14 Bioavailability of ingredients in dietary supplements : a practical approach to the in vitro demonstration of the availability of ingredients in dietary supplements 407

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