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Showing posts with label Toxicology. Show all posts
Showing posts with label Toxicology. Show all posts

Sunday, November 22, 2009

Handbook of Neurotoxicology, Volume 1

Posted by Piscean on Sunday, November 22, 2009 0 comments


Handbook of Neurotoxicology, Volume 1 (None)
By Edward J. Massaro

Publisher: Humana Press
Number Of Pages: 668
Publication Date: 2002-01-15
ISBN-10 / ASIN: 0896037959
ISBN-13 / EAN: 9780896037953
Binding: Hardcover

In the Handbook of Neurotoxicology, Volumes I and II, many leading researchers and clinicians-all acknowledged experts-review in depth the status of research in key areas of current neurotoxicologic interest and examine the latest methodologies for in vivo assessment of a wide spectrum of agents exhibiting neurotoxicologic properties. The first volume of the Handbook focuses on the biological effects of human-made neurotoxins, as well as those of natural origin, which so often provide valuable therapeutics and research reagents. Topics range from anticholinesterase insecticides and pesticides that target ion channels, to such metals as mercury, lead, zinc, and to the polytypic byproducts of combustion and industrial manufacture. The natural toxins discussed include those of microbial origin (microbial, marine, clostridial, and botulilinal neurotoxins), as well as those of animal origin (snake, spider, and scorpion venoms). The second volume concentrates on the biological effects of human-made toxins on the developing nervous system, reviews the neuronal impact of drugs of abuse, and provides state-of-the-art methods for the evaluation of the biological effects of neurotoxicants by both imaging and neurobehavioral assessment.


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Tuesday, November 17, 2009

Biomarker Methods in Drug Discovery and Development (Methods in Pharmacology and Toxicology)

Posted by Piscean on Tuesday, November 17, 2009 0 comments


Biomarker Methods in Drug Discovery and Development (Methods in Pharmacology and Toxicology)
By Feng Wang


Publisher: Humana Press
Number Of Pages: 20
Publication Date: 2008-03-10
ISBN-10 / ASIN: 1934115231
ISBN-13 / EAN: 9781934115237
Binding: Hardcover

Within the pharmaceutical industry, the improvement of drug discovery and development efficiency and the expected personalization of medicine have become vitally important issues. In Biomarker Methods in Drug Discovery and Development, expert researchers provide a tool box for those who have a general interest in biomarker research and for those currently specializing in certain technologies but desiring an understanding of other available methodologies. Its chapters include validated, mature methods as well as new, incredibly promising protocols which aim to apply multiple technologies at different molecular levels in order to surmount the monumental and complex task of transforming the pharmaceutical research anddevelopment processes. As a volume in the Methods in Pharmacology and Toxicology series, this book offers user-friendly, step-by-step laboratory protocols for readily reproducible experiments.

Comprehensive and state-of-the-art, Biomarker Methods in Drug Discovery and Development is the perfect biomarker technical guideline and reference to stimulate more exciting biomarker research and technology development.


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Tuesday, November 03, 2009

A Small Dose of Toxicology: The Health Effects of Common Chemicals

Posted by Piscean on Tuesday, November 03, 2009 0 comments

A Small Dose of Toxicology: The Health Effects of Common Chemicals
By Steven G. Gilbert


Publisher: Informa HealthCare
Number Of Pages: 280
Publication Date: 2004-02-25
ISBN-10 / ASIN: 0415311683
ISBN-13 / EAN: 9780415311687
Binding: Paperback


Everyday, we come into contact with many relatively harmless substances that could, at certain concentrations, be toxic. This applies not only to obvious candidates such as asbestos, lead, and gasoline, but also to compounds such as caffeine and headache tablets. While the field of toxicology has numerous texts devoted to aspects of biology, chemistry, and mechanism of action, the need remains for a book that places toxicology within the framework of our daily lives. A Small Dose of Toxicology presents the principles of toxicology by exploring the effects of common chemical agents such as caffeine, nicotine, and alcohol. It reviews the fundamentals of dose-response and factors of individual sensitivity in regard to these drugs, and then applies this knowledge to environmental contaminates such as lead, arsenic, pesticides, mercury, and radiation. Chapters discuss neurotoxicology, risk assessment, carcinogenicity, and with a variety of specific toxic agents, with each chapter designed as a self-contained module to allow for flexibility in the selection of personal or academic material. Exploring current toxicology concerns within a human context, this text discusses how toxicology affects our everyday lives while providing insight into the broader issues of public health and disease prevention. Environmental and public health professionals, as well as novices and students requiring a basic foundation in toxicology will find this resource incredibly useful.


Summary: Small Dose- but large information
Rating: 5

Steven Gilbert, Ph.D., DABT has compiled a user-friendly book of toxicology that has utility in beginner and advanced courses of the toxicology field. It is layman friendly and selectively includes toxic product hazards of everyday life. The common chemicals include alcohol, caffeine, nicotine, pesticides, lead, mercury, arsenic, heavy metals, solvents and radiation for starters; all products of human ingestion, inhalation or dermal absorption in everyday life. In simple terms and understandable paragraphs that are digestible, one learns of the dangers to human exposure. The additional reference lists at the end of each subject enhances the ability of one to research issues further. Government agencies that can assist the reader are also presented. Toxicology is literally “the science of poisons” and is often one of the “heaviest” curriculum/ biological subjects. “A Small Dose” allows the reader to enjoy the subject matter and still learn the issues at hand in the new millennium. Dr. Gilbert makes it palatable…Thank you! He was awarded a commendation in 2004 from the British Medical Association Library book competition- a most prestigious award.

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Wednesday, October 21, 2009

Cytochrome P450: Role in the Metabolism and Toxicity of Drugs and other Xenobiotics (Issues in Toxicology)

Posted by Piscean on Wednesday, October 21, 2009 0 comments


Cytochrome P450: Role in the Metabolism and Toxicity of Drugs and other Xenobiotics (Issues in Toxicology)
By Costas Ioannides

Publisher: Royal Society of Chemistry
Number Of Pages: 400
Publication Date: 2008-07-14
ISBN-10 / ASIN: 0854042741
ISBN-13 / EAN: 9780854042746

Product Description:

This much needed, new, fully up-to-date publication fills this gap and emphasizes the new relevant topics that have emerged during the last decade in an easily accessible manner.

The enzyme system,cP450, comprises a number of families/subfamilies, and the focus of the book is to deal with each individually, furnishing information directly relevant to scientists involved in the development of chemicals, in particular in the evaluation of their safety. The book has contributions from internationally respected scientists who are research-active in the relevant areas. The authors have made extensive use of figures and tables so that the reader can access the necessary information without always having to read the text. In addition, a very extensive, user-friendly index is a unique hallmark of the book.

Part A of this monograph introduces the reader to the current knowledge of the evolutionary development of cytochrome P450 structure and function. Furthermore, it deals with the role of this enzyme in the formation of reactive intermediates. The shrewd and extensive utilization of the molecular biology methodology very rapidly led to a vast body of enzymes calling for a classification of the plethora of different cytochromes P450 (the superfamily) into families and subfamilies. This is aptly exemplified by the ten chapters in Part B of this book, dealing with ten subfamilies and two families of cytochrome P450.
Part C offers an insight into another aspect of cytochrome P450 research, namely its regulation through receptor-mediated stimuli – as opposed to enzyme induction or inhibition.
The final chapter translates the current data on one of several drug metabolizing systems into clinical application and highlights the role of cytochromes P450 in the treatment of neoplastic growth.

The book deals extensively with each family/subfamily of the cytochromes P450 that contribute to the metabolism of xenobiotics.

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Wednesday, September 16, 2009

Poisoning & Drug Overdose, Fifth Edition

Posted by Piscean on Wednesday, September 16, 2009 0 comments


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