Posted by Piscean on Thursday, November 26, 2009
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By Jack P. Uetrecht, William Trager,
Publisher: Informa Healthcare Number Of Pages: 200 Publication Date: 2007-06-21 Sales Rank: 221863 ISBN / ASIN: 1420061038 EAN: 9781420061031 Binding: Paperback Manufacturer: Informa Healthcare Studio: Informa Healthcare
In order to understand drug metabolism at its most fundamental level, pharmaceutical scientists must be able to analyze drug compound structures and predict possible read.freeduan.com metabolic pathways in order to avoid the risk of adverse reactions that lead to the withdrawal of a drug from the market. This comprehensive textbook will aid in guiding students through the recognition of the chemical underpinnings of drug metabolism. While there are numerous resources available for understanding drug structure, and other texts relating to drug metabolism from a biological standpoint, there is no other resource currently available that links both the chemical and biological terminology together in a clear and concise language, written, to be accessible for use in the classroom, as an education tool for teaching drug development. Drug Metabolism: Chemical and Enzymatic Aspects explains, to teachers and students alike, how a drug is metabolized, the potential effects of the metabolites, extensive material to help understand drugmetabolism within a biological context, and practical problems and answers.
Posted by Piscean on Wednesday, October 21, 2009
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Cytochrome P450: Role in the Metabolism and Toxicity of Drugs and other Xenobiotics (Issues in Toxicology) By Costas Ioannides
Publisher: Royal Society of Chemistry Number Of Pages: 400 Publication Date: 2008-07-14 ISBN-10 / ASIN: 0854042741 ISBN-13 / EAN: 9780854042746
Product Description:
This much needed, new, fully up-to-date publication fills this gap and emphasizes the new relevant topics that have emerged during the last decade in an easily accessible manner.
The enzyme system,cP450, comprises a number of families/subfamilies, and the focus of the book is to deal with each individually, furnishing information directly relevant to scientists involved in the development of chemicals, in particular in the evaluation of their safety. The book has contributions from internationally respected scientists who are research-active in the relevant areas. The authors have made extensive use of figures and tables so that the reader can access the necessary information without always having to read the text. In addition, a very extensive, user-friendly index is a unique hallmark of the book.
Part A of this monograph introduces the reader to the current knowledge of the evolutionary development of cytochrome P450 structure and function. Furthermore, it deals with the role of this enzyme in the formation of reactive intermediates. The shrewd and extensive utilization of the molecular biology methodology very rapidly led to a vast body of enzymes calling for a classification of the plethora of different cytochromes P450 (the superfamily) into families and subfamilies. This is aptly exemplified by the ten chapters in Part B of this book, dealing with ten subfamilies and two families of cytochrome P450. Part C offers an insight into another aspect of cytochrome P450 research, namely its regulation through receptor-mediated stimuli – as opposed to enzyme induction or inhibition. The final chapter translates the current data on one of several drug metabolizing systems into clinical application and highlights the role of cytochromes P450 in the treatment of neoplastic growth.
The book deals extensively with each family/subfamily of the cytochromes P450 that contribute to the metabolism of xenobiotics.
Posted by Piscean on Wednesday, October 21, 2009
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A Handbook of Bioanalysis and Drug Metabolismis a stimulating new text that examines the techniques,methodology, and theory of bioanalysis, pharmacokinetics, and metabolism from the perspective of scientists with extensive professional experience in drug discovery and development. These three areas of research help drug developers to optimize the active component within potential drugs thereby increasing their effectiveness, and to provide safety and efficacy information required by regulators when granting a drug license. Professionals with extensive experience in drug discovery and development as well as specialized knowledge of the individual topics contributed to each chapter to create a current and well-credentialed text. It covers topics such as high performance liquid chromatography, protein binding, pharmacokinetics and drugdrug interactions. The unique industrial perspective helps to reinforce theory and develop valuable analytical and interpreting skills.
