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Monday, November 23, 2009

Foye's Principles of Medicinal Chemistry

Posted by Piscean on Monday, November 23, 2009 3 comments

Principles of Medicinal Chemistry
Sixth Edition
edited by Thomas L. Lemke

Foye's Principles of Medicinal Chemistry, 6th edition has been fully revised and updated. Emphasis is on patient-focused pharmaceutical care and on the pharmacist as a therapeutic consultant, rather than a chemist.

A new disease state management section explains appropriate therapeutic options for asthma, chronic obstructive pulmonary disease, and men's and women's health problems.

Also new to this edition:

  • Clinical Significance boxes
  • Drug Lists at the beginning of appropriate chapters
  • an eight-page color insert with detailed illustrations of drug structures


Part I: Principles of Drug Discovery

  1. Drug Discovery from Natural Products
  2. Drug Design and Relationship of Functional Groups to Pharmacologic Activity
  3. Molecular Modeling and in Silico
  4. Receptors and Drug Action
  5. Drug Discovery Through Enzyme Inhibition
  6. Pharmaceutical Biotechnology-From Nucleic Acids to Personalized Medicine
  7. Peptide and Protein Drugs
  8. Antisense Therapeutic Agents
  9. Physicochemical and Biopharmaceutical Properties of Drug Substances and Pharmacokinetics
  10. Drug Metabolism
  11. Drug Regulation: An Overview

Part II: Drug Receptors Affecting Neurotransmission and Enzymes as Catalytic Receptors

  1. Drugs Affecting Cholinergic Neurotransmission
  2. Adrenergic Receptors and Drugs Affecting Adrenergic Neurotransmission
  3. Serotonin Receptors and Drugs Affecting Serotonergic Neurotransmission
  4. Amino Acid Neurotransmitters in the Central Nervous System
  5. Inhibitors of Nerve Conduction: Local Anesthetics
  6. Phosphodiesterase Inhibitors

Part III: Pharmacodynamic Agents

Section 1: Drugs Affecting Central Nervous System

  1. General Anesthetics
  2. Sedative-Hypnotics
  3. Antiseizure Agents
  4. Antidepressants
  5. Psychotherapeutic Drugs: Antipsychotic and Anxiolytic Agents
  6. Hallucinogens, Stimulants and Related Drugs of Abuse
  7. Opioid Analgesics
  8. Drugs Used to Treat Neuromuscular Disorders: Antiparkinsonian and Spasmolytic Agents

Section 2: Drugs Affecting the Cardiovascular System

  1. Cardiac Agents: Cardiac Glycosides, Antianginal, and Antiarrhythmic Drugs
  2. Diuretics
  3. Angiotensin Converting Enzyme Inhibitors, Antagonists and Calcium Blockers
  4. Central and Peripheral Sympatholytics and Vasodilators
  5. Antihyperlipoproteinemics and Inhibitors of Cholesterol Biosynthesis
  6. Antithrombotics, Thrombolytics, Coagulants, and Plasma Extenders

Section 3: Drugs Affecting the Hormonal Systems

  1. Insulin and Drugs Used for the Treatment of Diabetes
  2. Adrenocorticoids
  3. Thyroid Function and Thyroid Drugs
  4. Calcium Homeostasis Section 4: Drugs Affecting the Immune Systems

Section 4: Drugs Affecting the Immune System

  1. Nonsteroidal Anti-Inflammatory Drugs
  2. Antihistamines and Related Antiallergic and Antiulcer Agents

Section 5: Chemotherapeutic Agents

  1. Antibiotics and Antimicrobial Agents
  2. Antiparasitic Agents
  3. Antifungal Agents
  4. Antimycobacterial Agents
  5. Cancer and Chemotherapy
  6. Antiviral Agents and Protease Inhibitors

Part IV: Disease State Management

  1. Asthma and Chronic Obstructive Pulmonary Disease
  2. Men' Health
  3. Women's Health


  • pKa Values for Some Drugs and Miscellaneous Organic Acids and Bases
  • pH Values for Tissue Fluids


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